You will need a simple, class-compliant USB-to-MIDI cable adapter (such as the iConnectivity mio, Roland UM-ONE, or a budget alternative).
This is the most common driver‑failure scenario. After a major macOS upgrade, the existing 32‑bit driver is disabled. Follow the installation steps for the open‑source driver, making sure to any remnants of the old M‑Audio driver first. Failure to remove the old MIDI driver can cause conflicts that prevent the new 64‑bit driver from loading properly. m-audio radium 49 driver mac
Which (Logic, GarageBand, Ableton, etc.) are you trying to use? You will need a simple, class-compliant USB-to-MIDI cable
This method requires modifying system permissions and can be unstable across major macOS updates (e.g., moving from Ventura to Sonoma). Method 3: The "Class-Compliant" Workaround (If Applicable) Follow the installation steps for the open‑source driver,
Ensure the "Radium 49" or "USB MIDI Device" is enabled for Input. Troubleshooting: What to Do If It Doesn’t Work